Pathology of Progression

EpubLassmann H. Pathology and disease mechanisms in different stages of multiple sclerosis. J Neurol Sci. 2013 Jun 1. 

In this review the differences in pathology and disease mechanisms between early and late stages of multiple sclerosis are discussed. The data suggest that affection of the brain is different, depending on the location of lesions, on the stage of the disease, when lesions arise, and on inter-individual differences between patients. We suggest that in the early stage of the disease new lesions are formed by new waves of inflammatory cells, entering the central nervous system from the circulation and giving rise to focal demyelinated plaques in the white and gray matter. In contrast, at late stages of the disease inflammation decreases, but the susceptibility of the target tissue for neurodegeneration increases. New data suggest that mitochondrial injury, mediated through oxidative injury, is in the center of the pathogenetic events leading to brain damage in multiple sclerosis patients.

 

As part of the International Progressive MS Collaborative it is clear that understanding the cause and pathology of progression is  a central part of the problem, when you try to think about trying to model and treat it. 

Therefore, it is timely that Prof Lassmann from Vienna has focussed his ideas. 

If you are a Pathologist reading this post..It is time for others to focus their ideas too. 

Will they all agree?.......Can you herd cats?

Team G are on the mitochondrial trail already in more ways that one. 

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